化工社化工社 化学情報印刷レポート · 研究参考用
Flutamide → N-[4-Amino-3-(trifluoromethyl)phenyl]-2-methylpropanamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Flutamide | HCID 3397 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N-[4-Amino-3-(trifluoromethyl)phenyl]-2-methylpropanamide | HCID 16776651 | — |
反応手順
Hydrogenate, at approximately 3 atmospheres, a mixture of 8.3 g. of 4'-nitro-3'-trifluoromethylisobutyranilide in 100 ml. of ethanol containing 0.5 g. of 5% palladium on charcoal. Filter and remove the solvent, obtaining 4'-amino-3'-trifluoromethylisobutyranilide, m.p. 114.5°-116° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04144270 |
| 出典データセット | uspto-grants-1979_03 |
| ORD ID | ord-02a1de3a5d9142449202be4dd9fa9066 |
| 出典メモ | uspto-grants-1979_03 |