2,5-Dimethoxytetrahydrofuran → 2-chloro-3-(1H-pyrrol-1-yl)pyridine
反応式
[Cl:1][C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[CH:4][N:3]=1.CO[CH:11]1[CH2:15][CH2:14][CH:13](OC)O1>C(O)(=O)C>[Cl:1][C:2]1[C:7]([N:8]2[CH:11]=[CH:15][CH:14]=[CH:13]2)=[CH:6][CH:5]=[CH:4][N:3]=1参加物
4
実験手順
A solution of acetic acid (25 ml), 2-chloro-3-aminopyridine (5.1 g, 0.04 m) and 2,5-dimethoxytetrahydrofuran (0.05 m) was heated to reflux. After two hours, the mixture was concentrated to dryness, treated with ice and neutralized with saturate Na2CO3 solution. The aqueous layer was extracted with CHCl3 (3×100 ml). The organic extract was dried over Na2SO4, filtered and concentrated to dryness. The residue was distilled to yield 5.3 g (75% yield) of 2-chloro-3-(1-pyrrolyl) pyridine; b.p=95°-100° at 0.5 mm.
後処理
- concentrationthe mixture was concentrated to dryness
- additiontreated with ice and neutralized with saturate Na2CO3 solution
- extractionThe aqueous layer was extracted with CHCl3 (3×100 ml)
- extractionThe organic extract
- dry with materialwas dried over Na2SO4
- filtrationfiltered
- concentrationconcentrated to dryness
- distillationThe residue was distilled
出典と根拠
- ORDレコード
- ord-32c4a8437d274ca7afb03a459bfa139a
- 出典データセット
- uspto-grants-1979_03
- 特許番号
- US04144343
反応ノート
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