Butyl bromide → HCID 21329306、化合物

HRID 614347ノート

反応式

HRID 614347 の反応式
[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([N:10]3[C:14]4=[N:15][CH:16]=[CH:17][CH:18]=[C:13]4[NH:12][C:11]3=[O:19])=[CH:4][C:3]=2[O:2]1.[OH-].[K+].Br[CH2:23][CH2:24][CH2:25][CH3:26]>CC(C)=O>[CH2:23]([N:12]1[C:13]2[C:14](=[N:15][CH:16]=[CH:17][CH:18]=2)[N:10]([C:5]2[CH:6]=[CH:7][C:8]3[O:9][CH2:1][O:2][C:3]=3[CH:4]=2)[C:11]1=[O:19])[CH2:24][CH2:25][CH3:26]

参加物

5

反応物 3

HCID 8002Butyl bromideHCID 14797Potassium HydroxideHCID 119617392H-Imidazo[4,5-b]pyridin-2-one, 3-(1,3-benzodioxol-5-yl)-1,3-dihydro-

生成物 1

HCID 21329306HCID 21329306、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a suspension of 2.6 g. (0.01 mole) of 1,3-dihydro-3-(3,4-methylenedioxyphenyl)imidazo[4,5-b]-pyridin-2-one in 150 ml. of acetone, was added 1.12 g. (0.02 mole) of powdered potassium hydroxide. The mixture was stirred at room temperature for 20 minutes and 2.74 g. (0.02 mole) of 1-bromobutane was added. The mixture was stirred at reflux for 16 hours and then evaporated in vacuo. The residue was extracted with a solution of 20 ml. of 2.5 N sodium hydroxide and 50 ml. of water. The product was separated by filtration and was purified by crystallization from ether-petroleum ether giving 2.4 g. of white needles melting at 74°-75° C.

後処理

  1. additionTo a suspension of 2.6 g
  2. stirringThe mixture was stirred
  3. temperatureat reflux for 16 hours
  4. customevaporated in vacuo
  5. extractionThe residue was extracted with a solution of 20 ml
  6. customThe product was separated by filtration
  7. customwas purified by crystallization from ether-petroleum ether giving 2.4 g

出典と根拠

ORDレコード
ord-c3ca62fefccb47778086dfc0f31d5ffc
出典データセット
uspto-grants-1979_03
特許番号
US04144341

反応ノート

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