化工社化工社 化学情報印刷レポート · 研究参考用
Nitric Acid → 3-Bromo-2-nitro-1-benzofuran
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Nitric Acid | HCID 944 | — |
| 反応物 | 3-Bromo-1-benzofuran | HCID 640589 | — |
| 反応物 | Sodium Nitrite | HCID 23668193 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 3-Bromo-2-nitro-1-benzofuran | HCID 13509842 | — |
反応手順
A 5.0 g. sample of powdered 3-bromobenzofuran on a glass dish is placed next to a container of nitric acid. Sodium nitrite is added periodically to the nitric acid, and the entire experiment is covered with a bell jar. After about 15 minutes the powder becomes an oil. After 12 hours the product is dissolved in hot methanol and slowly crystallized by cooling. Recrystallization from methanol provides yellow crystals of 3-bromo-2-nitrobenzofuran, m.p. 130°-132° C. (lit. 132° C.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04144347 |
| 出典データセット | uspto-grants-1979_03 |
| ORD ID | ord-e8b879d8638c47dbba8295506a30c2d9 |
| 出典メモ | uspto-grants-1979_03 |