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2-(cis-2,6-Dimethyl-1-piperidinyl)ethanamine → cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-5,5-dimethyl-2-oxo-1-pyrrolidineacetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(cis-2,6-Dimethyl-1-piperidinyl)ethanamine | HCID 783702 | — |
| 反応物 | Ethyl 2,2-dimethyl-5-oxopyrrolidineacetate | HCID 21327791 | — |
| 生成物 | cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-5,5-dimethyl-2-oxo-1-pyrrolidineacetamide | HCID 70609679 | — |
反応手順
From 10 g. of ethyl 2,2-dimethyl-5-oxo-1-pyrrolidineacetate and 11 g. of cis-2-(2,6-dimethyl-1-piperidinyl)ethylamine, following the procedure of Example 9, there is obtained cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-5,5-dimethyl-2-oxo-1-pyrrolidineacetamide as the hemihydrate; m.p. 94°-94.5° C. after recrystallization from isooctane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04145347 |
| 出典データセット | uspto-grants-1979_03 |
| ORD ID | ord-598508840ffa4da0adac05ffe4e0cd5b |
| 出典メモ | uspto-grants-1979_03 |