cis-3-[2,6-Dimethylpiperidinyl]propylamine → cis-(+/-)-N-[3-(2,6-dimethyl-1-piperidinyl)propyl]-alpha-methyl-2-oxo-1-pyrrolidineacetamide
反応式
[CH3:1][CH:2]([N:8]1[CH2:12][CH2:11][CH2:10][C:9]1=[O:13])[C:3]([O:5]CC)=O.[CH3:14][C@H:15]1[CH2:20][CH2:19][CH2:18][C@@H:17]([CH3:21])[N:16]1[CH2:22][CH2:23][CH2:24][NH2:25]>>[CH3:14][C@H:15]1[CH2:20][CH2:19][CH2:18][C@@H:17]([CH3:21])[N:16]1[CH2:22][CH2:23][CH2:24][NH:25][C:3](=[O:5])[CH:2]([CH3:1])[N:8]1[CH2:12][CH2:11][CH2:10][C:9]1=[O:13]参加物
3
実験手順
From 9.25 g. of ethyl α-methyl-2-oxo-1-pyrrolidineacetate and 10.5 g. of cis-3-(2,6-dimethyl-1-piperidinyl)propylamine, following the procedure of Example 21, there is obtained cis-(±)-N-[3-(2,6-dimethyl-1-piperidinyl)propyl]-α-methyl-2-oxo-1-pyrrolidineacetamide; b.p. 165°-170° C./0.1 mm.
出典と根拠
- ORDレコード
- ord-80f1fc880dbf4760a606967af394d539
- 出典データセット
- uspto-grants-1979_03