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Propynamide → 5,6-Dihydro-5-oxopyrazolo[1,5-c]quinazoline-2-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Propynamide | HCID 101445 | — |
| 反応物 | (3Z)-3-diazo-1H-indol-2-one | HCID 136455454 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | 5,6-Dihydro-5-oxopyrazolo[1,5-c]quinazoline-2-carboxamide | HCID 135735615 | 13.1% |
反応手順
4.8 g (0.03 mole) of 3-diazooxindole and 2.4 g (0.035 mole) of the propiolamide are taken up in benzene (250 ml) and refluxed overnight under a stream of nitrogen. The light tan precipitates that form are filtered off and dried in a vacuum oven for 4 hours. Yield: 4.4 g. Additional refluxing of the filtrate gives 900 mg of product. Total yield: 5.3 g (77.4%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04145420 |
| 出典データセット | uspto-grants-1979_03 |
| ORD ID | ord-8f14655529db4b009c8a3304b7cd41c5 |
| 出典メモ | uspto-grants-1979_03 |