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Hydrochloric Acid → 2-[2-(5-Methyl-4-imidazolylmethylthio)-ethylamino]-5-(2-phenylethyl)-4-pyrimidone dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 2(1H)-Pyrimidinone | HCID 68401 | — |
| 反応物 | 4-(((2-Aminoethyl)thio)methyl)-5-methylimidazole | HCID 665568 | — |
| 反応物 | 5-(2-Phenylethyl)-2-thiouracil | HCID 12945971 | — |
| 反応物 | 5-Phenylethyl-2-methylthio-4-pyrimidone | HCID 12951508 | — |
| 生成物 | 2-[2-(5-Methyl-4-imidazolylmethylthio)-ethylamino]-5-(2-phenylethyl)-4-pyrimidone dihydrochloride | HCID 23346171 | — |
反応手順
5-(2-Phenylethyl)-2-thiouracil (1.8 g) was converted into 5-phenylethyl-2-methylthio-4-pyrimidone (m.p. 160°-161° ex ethanol) by the method described in Example 1(i). Reaction of this pyrimidone (1.55g) with 2-(5-methyl-4-imidazolylmethylthio)-ethylamine (1.1 g) by the method described in Example 1(ii) gave an oil which was dissolved in 2N hydrochloric acid, the solution evaporated to dryness and the residue recrystallised from methanol to give 2-[2-(5-methyl-4-imidazolylmethylthio)-ethylamino]-5-(2-phenylethyl)-4-pyrimidone dihydrochloride, m.p. 214°-218°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04145546 |
| 出典データセット | uspto-grants-1979_03 |
| ORD ID | ord-af83002c64c44d3c8e68996d9b692e00 |
| 出典メモ | uspto-grants-1979_03 |