化工社化工社 化学情報印刷レポート · 研究参考用
Acetone → Hydrochloric Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetone | HCID 180 | — |
| 反応物 | Potassium Iodide | HCID 4875 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | N,N-Dimethylaminoethyl chloride hydrochloride | HCID 11636816 | — |
| 反応物 | 4-Trifluoromethylphenylchroman-7-ol | HCID 86735563 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | Hydrochloric Acid | HCID 313 | — |
| 生成物 | Brl 16657 | HCID 42989 | — |
反応手順
Dimethylaminoethylchloride hydrochloride (1.5 g) was added to 2,2-dimethyl-4-(4-trifluoromethylphenylchroman-7-ol (1.0 g), potassium carbonate (4.0 g) and potassium iodide (1.5 g) in acetone (50 ml) and the mixture refluxed for 2 days. The mixture was filtered and the acetone was evaporated under reduced pressure. The resulting crude oil was chromatographed on alumina. Elution with ether:petrol (1:1) gave a clear oil which after dissolution in dry ether and passage of dry hydrogen chloride through the solution yielded the required chroman as the hydrochloride salt (0.35 g), m.p. 200°-203° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04146539 |
| 出典データセット | uspto-grants-1979_03 |
| ORD ID | ord-a3c5271b8cea44cb9fea1ac91cfd4c81 |
| 出典メモ | uspto-grants-1979_03 |