Sulfuric Acid → HCID 21873086、化合物
反応式
[C:1](#[N:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:9][C:10]([Cl:19])([Cl:18])[CH:11](O)[NH:12][C:13](=[O:16])[CH2:14][Cl:15].S(=O)(=O)(O)[OH:21]>>[Cl:9][C:10]([Cl:18])([Cl:19])[CH:11]([NH:8][C:1](=[O:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[NH:12][C:13](=[O:16])[CH2:14][Cl:15]参加物
4
実験手順
Benzonitrile (5.2g) was added dropwise to a solution of 1,1,1-trichloro-2-hydroxy-2-(chloroacetamido)ethane (12.05g) in concentrated sulphuric acid (50 ml). The temperature was kept at 0° during the addition. The mixture was stirred at room temperature for 4 hours, then left overnight. The reaction mixture was poured on to ice. The precipitated solid was collected, washed with water and dried (19.6g). Recrystallisation from nitromethane gave pure 1,1,1-trichloro-2-benzamido-2-(chloroacetamido)ethane (14.6g, m.p. 210°-12°)
後処理
- additionThe temperature was kept at 0° during the addition