化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → Norfloxacin hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Norfloxacin | HCID 4539 | — |
| 反応物 | 1-Ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid pentahydrate | HCID 70603524 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Norfloxacin hydrochloride | HCID 12733888 | — |
反応手順
The compound (I) or (II) was dissolved in ethanol and acidified with concentrated hydrochloric acid. The resulting precipitate was collected, washed with ethanol, and dried to give 1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrochloride (III) as colorless needles, m.p. above 300° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04146719 |
| 出典データセット | uspto-grants-1979_03 |
| ORD ID | ord-9db6c02d96a74a82888d23a4fe2324b2 |
| 出典メモ | uspto-grants-1979_03 |