化工社化工社 化学情報印刷レポート · 研究参考用
Norfloxacin → 1-Ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid pentahydrate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Norfloxacin | HCID 4539 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Sodium Hydroxide | HCID 14798 | — |
| 生成物 | 1-Ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid pentahydrate | HCID 70603524 | — |
反応手順
The compound (II) was dissolved in 10% sodium hydroxide and neutralized with acetic acid. The precipitate was washed with water and dried at room temperature to afford 1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrate (I) as colorless powder, m.p.: 226°-227° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04146719 |
| 出典データセット | uspto-grants-1979_03 |
| ORD ID | ord-cd84b54551eb4287bbcf73cd49f6b746 |
| 出典メモ | uspto-grants-1979_03 |