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3,3-Dibenzoylpropionic acid ethyl ester → 3,5-Diphenyl-1-(3-pyridyl)-pyrazol-4-acetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,3-Dibenzoylpropionic acid ethyl ester | HCID 10852438 | — |
| 反応物 | 3-Hydrazinopyridine | HCID 10909519 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 3,5-Diphenyl-1-(3-pyridyl)-pyrazol-4-acetic acid | HCID 20542800 | 62% |
反応手順
8.7 grams 3,3-dibenzoyl-propionic acid ethyl ester, 5.0 grams 3-hydrazino-pyridine and 6.0 grams glacial acetic acid were mixed and the mixture heated to the boiling temperature under reflux for 5 hours. The reaction product was further processed by a procedure analogous to that described in Example (2a). 6.1 grams 3,5-diphenyl-1-(3-pyridyl)-pyrazol-4-acetic acid, melting at 185°-187° C., were obtained, representing a yield of 62%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04146721 |
| 出典データセット | uspto-grants-1979_03 |
| ORD ID | ord-8510306f07334b3fbb59502db488a531 |
| 出典メモ | uspto-grants-1979_03 |