Hydrochloric Acid → HCID 15580438、化合物

HRID 615163ノート

反応式

HRID 615163 の反応式
Cl.O.C([NH:6][C:7]1[CH:24]=[CH:23][C:10]2[N:11]3[CH:16]=[C:15]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)[N:14]=[C:12]3[S:13][C:9]=2[CH:8]=1)(=O)C>COCCO>[NH2:6][C:7]1[CH:24]=[CH:23][C:10]2[N:11]3[CH:16]=[C:15]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)[N:14]=[C:12]3[S:13][C:9]=2[CH:8]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 70491659HCID 70491659、化合物

生成物 1

HCID 15580438HCID 15580438、化合物収率 83.1%

試薬・触媒・溶媒 1

HCID 80192-Methoxyethanol溶媒

実験手順

To a mixture of 100 ml of concentrated hydrochloric acid solution and 300 ml of methylcellosolve was added 8.5 g of 7-acetamido-2-phenylimidazo[2,1-b]benzothiazole mono-hydrate and the mixture was stirred for 4 hours at 100°-110° C. The reaction mixture was cooled to form crystals, which were recovered by filtration. The crystals were suspended in 200 ml of methylcellosolve and after alkalifying the suspension by adding concentrated aqueous ammonia, 80 ml of water was added to the mixture followed by cooling, thereby crystals precipitated. The crystals precipitated were recovered by filtration and dried to provide 5.76 g of 7-amino-2-phenylimidazo[2,1-b]benzothiazole.

後処理

  1. temperatureThe reaction mixture was cooled
  2. customto form crystals, which
  3. filtrationwere recovered by filtration
  4. additionby adding concentrated aqueous ammonia, 80 ml of water
  5. additionwas added to the mixture
  6. temperatureby cooling
  7. customcrystals precipitated
  8. customThe crystals precipitated
  9. filtrationwere recovered by filtration
  10. customdried

出典と根拠

ORDレコード
ord-aeea73616b844914905167f9758f3f60
出典データセット
uspto-grants-1985_02
特許番号
US04497817

反応ノート

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