Hydrochloric Acid → 2-Hydroxyethyl 2-methyl-4-(3-nitrophenyl)-5-oxo-5,7-dihydrofuro(3,4-b)pyridine-3-carboxylate

反応式

[K].[OH:2][CH2:3][CH2:4][O:5][C:6]([C:8]1[C:9]([C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([N+:26]([O-:28])=[O:27])[CH:21]=2)=[C:10]([C:17](O)=[O:18])[C:11]([CH2:15][OH:16])=[N:12][C:13]=1[CH3:14])=[O:7].Cl>O>[CH3:14][C:13]1[N:12]=[C:11]2[CH2:15][O:16][C:17](=[O:18])[C:10]2=[C:9]([C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([N+:26]([O-:28])=[O:27])[CH:21]=2)[C:8]=1[C:6]([O:5][CH2:4][CH2:3][OH:2])=[O:7]

参加物

実験手順

4 g of potassium salt of 2-hydroxymethyl-6-methyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 5-(2-hydroxyethyl) ester (Example 52) were dissolved in 4 ml of water and acidified with concentrated hydrochloric acid. After standing overnight at room temperature, the mixture was diluted with water, the oil which separated out was extracted with methylene chloride, the organic extracts, after drying over sodium sulphate, were evaporated in vacuo and the residue was recrystallized from isopropanol, melting point 130° C.