Phosgene → 2-Benzyloxybenzyl isocyanate

HRID 615223ノート

反応式

HRID 615223 の反応式
Cl.[CH2:2]([O:9][C:10]1[CH:17]=[CH:16][CH:15]=[CH:14][C:11]=1[CH2:12][NH2:13])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[C:18](Cl)(Cl)=[O:19]>C1(C)C=CC=CC=1>[CH2:2]([O:9][C:10]1[CH:17]=[CH:16][CH:15]=[CH:14][C:11]=1[CH2:12][N:13]=[C:18]=[O:19])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 6371Phosgene2 回HCID 13754433[2-(Benzyloxy)phenyl]methanamine hydrochloride

生成物 1

HCID 137544342-Benzyloxybenzyl isocyanate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

実験手順

38.5 g of 2-benzyloxybenzylamine hydrochloride are suspended in 400 ml of distilled toluene and heated at a bath temperature of 140°. Whilst stirring, phosgene is introduced and after about 50 minutes the solution becomes clear. After a further 10 minutes, the addition of phosgene is interrupted and boiling is continued for a further hour. The solution is then left to cool a little and the toluene is distilled off in vacuo. A sample of the oil remaining was distilled in a bulb tube: Boiling point, bath temperature 120°/0.06 torr.

後処理

  1. temperatureheated at a bath temperature of 140°
  2. waitboiling is continued for a further hour
  3. waitThe solution is then left
  4. distillationis distilled off in vacuo
  5. distillationA sample of the oil remaining was distilled in a bulb tube
  6. customBoiling point, bath temperature 120°/0.06 torr

出典と根拠

ORDレコード
ord-a9417eda979d4b9998ffbd25716e3636
出典データセット
uspto-grants-1985_02
特許番号
US04497813

反応ノート

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