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Triethylamine → 3-Isoquinolinecarboxamide, 1-(2-chlorophenyl)-N,N-dipropyl-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Dipropylamine | HCID 8902 | — |
| 反応物 | Ethyl chloroformate | HCID 10928 | — |
| 反応物 | 3-Isoquinolinecarboxylicacid, 1-(2-chlorophenyl)- | HCID 11000554 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 3-Isoquinolinecarboxamide, 1-(2-chlorophenyl)-N,N-dipropyl- | HCID 11057656 | 76.2% |
反応手順
Operations are carried out as for Example 7, starting from 1.42 g of 1-(2-chlorophenyl) isoquinoline 3-carboxylic acid, 0.58 g of triethylamine, 0.62 g of ethyl chloroformate and 0.66 g of N-propyl propylamine in 50 ml of chloroform. 1.40 g of N,N-dipropyl 1-(2-chloro phenyl) isoquinoline 3-carboxamide, melting at 101° C., are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04499094 |
| 出典データセット | uspto-grants-1985_02 |
| ORD ID | ord-7dd1cd01cc0444419ddd184d7320cb67 |
| 出典メモ | uspto-grants-1985_02 |