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N-Methylcyclohexylamine → 1-(2-Chlorophenyl)-N-cyclohexyl-N-methylisoquinoline-3-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Methylcyclohexylamine | HCID 7514 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Ethyl chloroformate | HCID 10928 | — |
| 反応物 | 3-Isoquinolinecarboxylicacid, 1-(2-chlorophenyl)- | HCID 11000554 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 1-(2-Chlorophenyl)-N-cyclohexyl-N-methylisoquinoline-3-carboxamide | HCID 13272372 | 64.8% |
反応手順
Operations are carried out as for Example 7, starting from 2.83 g of 1-(2-chloro phenyl) isoquinoline 3-carboxylic acid, 1.15 g of triethylamine, 1.24 g of ethyl chloroformate and 1.46 g of N-methyl cyclohexylamine in 100 ml of chloroform. 2.45 g of N-cyclohexyl N-methyl 1-(2-chloro phenyl) isoquinoline 3-carboxamide melting at 131° C., are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04499094 |
| 出典データセット | uspto-grants-1985_02 |
| ORD ID | ord-eaa46ff13785440fb25db1db329e3ed3 |
| 出典メモ | uspto-grants-1985_02 |