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Triethylamine → 2(R)-ethyl 1-[(1-phenyl 3-isoquinolyl) carbonyl]piperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Ethyl chloroformate | HCID 10928 | — |
| 反応物 | 1-Phenylisoquinoline-3-carboxylic acid | HCID 407896 | — |
| 反応物 | (R)-2-Ethylpiperidine hydrochloride | HCID 18596119 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2(R)-ethyl 1-[(1-phenyl 3-isoquinolyl) carbonyl]piperidine | HCID 24842682 | 57.9% |
反応手順
Operations are carried out as for Example 7, starting from 2.5 g of 1-phenyl isoquinoline 3-carboxylic acid, 2.86 g of triethylamine, 1.24 g of ethyl chloroformate and 1.93 g of 2(R)-ethyl piperidine hydrochloride in 100 ml of toluene. After chromatography, 2 g of 2(R)-ethyl 1-[(1-phenyl 3-isoquinolyl) carbonyl]piperidine in the form of oil are obtained. αD26 =+1.4° (2% in ethanol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04499094 |
| 出典データセット | uspto-grants-1985_02 |
| ORD ID | ord-4e313db4a4574cf1a2f5d32a6112034f |
| 出典メモ | uspto-grants-1985_02 |