Hydrochloric Acid → Methyl 3-acetylbenzoate

HRID 615497ノート

反応式

HRID 615497 の反応式
[C:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7]([OH:9])=[O:8])(=[O:3])[CH3:2].Cl.[CH3:14]O>>[C:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7]([O:9][CH3:14])=[O:8])(=[O:3])[CH3:2]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 2203243-Acetylbenzoic acid

生成物 1

HCID 15094405Methyl 3-acetylbenzoate

実験手順

A solution of 5 g of 3-acetylbenzoic acid in dry MeOH was saturated with hydrogen chloride gas. The reaction vessel was stoppered and kept at room temperature for 2 days. The MeOH was evaporated and the residue extracted into diethylether and clarified by filtration. The ether was evaporated and the dark oil was chromatographed through a short column of silica gel eluting with methylene chloride. The combined fractions were evaporated to dryness giving 4.25 g of a yellow oil that solidified on standing. The solid ester was used as obtained.

後処理

  1. customThe MeOH was evaporated
  2. extractionthe residue extracted into diethylether
  3. filtrationclarified by filtration
  4. customThe ether was evaporated
  5. customthe dark oil was chromatographed through a short column of silica gel eluting with methylene chloride
  6. customThe combined fractions were evaporated to dryness

出典と根拠

ORDレコード
ord-2a55d678a4c84c3cb89e75fb0aae551e
出典データセット
uspto-grants-1985_02
特許番号
US04499299

反応ノート

読み込み中…