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Potassium Carbonate → Methyl 4-(4-acetyl-3-hydroxy-2-propylphenoxy)methylcinnamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2',4'-Dihydroxy-3'-propylacetophenone | HCID 2775198 | — |
| 反応物 | Methyl 3-(4-(bromomethyl)phenyl)-2-propenoate | HCID 53395294 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | Methyl 4-(4-acetyl-3-hydroxy-2-propylphenoxy)methylcinnamate | HCID 54184243 | 53.2% |
反応手順
A mixture of 1.0 g (5.15 g) of 2,4-dihydroxy-3-propylacetophenone, 1.58 g (6.18 mmol) of methyl 4-bromomethylcinnamate and 0.85 g (6.18 mmol) of anhydrous potassium carbonate in 20 ml of acetone was stirred at reflux for 18 hours. Ether extraction gave 1.01 g of the title compound as a light yellow powder mp 121°-125° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04499299 |
| 出典データセット | uspto-grants-1985_02 |
| ORD ID | ord-54625bde50e149b2b0aec41b07c0f373 |
| 出典メモ | uspto-grants-1985_02 |