Thiophene-2-sulfonyl isocyanate → N-[N-[4-(2,2,2-trifluoroethoxy)-6-methylpyrimidin-2-yl]-N-methylaminocarbonyl]-2-thiophenesulfonamide
反応式
[CH3:1][NH:2][C:3]1[N:8]=[C:7]([O:9][CH2:10][C:11]([F:14])([F:13])[F:12])[CH:6]=[C:5]([CH3:15])[N:4]=1.[S:16]1[CH:20]=[CH:19][CH:18]=[C:17]1[S:21]([N:24]=[C:25]=[O:26])(=[O:23])=[O:22]>C(Cl)Cl>[F:14][C:11]([F:12])([F:13])[CH2:10][O:9][C:7]1[CH:6]=[C:5]([CH3:15])[N:4]=[C:3]([N:2]([CH3:1])[C:25]([NH:24][S:21]([C:17]2[S:16][CH:20]=[CH:19][CH:18]=2)(=[O:22])=[O:23])=[O:26])[N:8]=1参加物
4
実験手順
To a dry stirred solution of 22.1 parts of 2-methylamino-4-(2,2,2-trifluorethoxy)-6-methylpyrimidine in 250 parts of methylene chloride at ambient temperature was added 18.9 parts of 2-thiophenesulfonyl isocyanate. That mixture was stirred and refluxed for 2 hours. The methylene chloride was removed under reduced pressure, and the resulting solid was triturated with toluene to yield 19 parts of N-[N-[4-(2,2,2-trifluoroethoxy)-6-methylpyrimidin-2-yl]-N-methylaminocarbonyl]-2-thiophenesulfonamide.