Ammonium Hydroxide → 4-Methyl-2-phenyloxazole-5-carboxamide

HRID 616014ノート

反応式

HRID 616014 の反応式
[OH-].[NH4+:2].[C:3]([C:8]1[O:12][C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[N:10][C:9]=1[CH3:19])(OCC)=[O:4]>C(O)C>[C:3]([C:8]1[O:12][C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[N:10][C:9]=1[CH3:19])(=[O:4])[NH2:2]

参加物

4

反応物 2

HCID 14923Ammonium HydroxideHCID 12282208ethyl 4-methyl-2-phenyl-1,3-oxazole-5-carboxylate

生成物 1

HCID 727634-Methyl-2-phenyloxazole-5-carboxamide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

150 Ml. (2.5 mole) of concentrated ammonium hydroxide is added dropwise to a solution of 10 g. (0.0434 mole) of 5-carbethoxy-2-phenyl-4-methyloxazole in 150 ml. of 95% ethanol. The mixture is stirred three days at room temperature, then it is concentrated to 50 ml. by evaporating the ethanol and chilled. The precipitated product is filtered, washed, dried over sodium sulfate and recrystallized from methanol; yield 3.7 g. of the title compound; m.p. 187°-190°.

後処理

  1. concentrationit is concentrated to 50 ml
  2. customby evaporating the ethanol
  3. temperaturechilled
  4. filtrationThe precipitated product is filtered
  5. washwashed
  6. dry with materialdried over sodium sulfate
  7. customrecrystallized from methanol

出典と根拠

ORDレコード
ord-41a18a3b133e47a28f4c0d53ffcb7d5b
出典データセット
uspto-grants-1978_02
特許番号
US04072689

反応ノート

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