Acetic Anhydride → HCID 3046378、化合物

HRID 616037ノート

反応式

HRID 616037 の反応式
Br.[CH2:2]([N:5]1[CH2:10][CH2:9][CH2:8][CH:7]([C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[C:13]([OH:18])[CH:12]=2)[CH2:6]1)[CH2:3][CH3:4].[C:19]([O-:22])(=O)[CH3:20].[Na+].[C:24](OC(=O)C)(=[O:26])[CH3:25]>>[CH2:2]([N:5]1[CH2:10][CH2:9][CH2:8][CH:7]([C:11]2[CH:16]=[CH:15][C:14]([O:17][C:24](=[O:26])[CH3:25])=[C:13]([O:18][C:19](=[O:22])[CH3:20])[CH:12]=2)[CH2:6]1)[CH2:3][CH3:4]

参加物

4

反応物 3

HCID 7918Acetic AnhydrideHCID 517045Sodium AcetateHCID 30463764-(1-Propylpiperidin-3-yl)benzene-1,2-diol--hydrogen bromide (1/1)

生成物 1

HCID 3046378HCID 3046378、化合物

実験手順

A suspension of 3.5 g of N-propyl-3-(3',4'-dihydroxyphenyl)-piperidine hydrobromide in 40 ml of acetic acid anhydride was stirred with 3.5 g of sodium acetate for 3 hours at 20° C and the mixture was then filtered. The filtrate was evaporated to dryness and the residue was taken up in a water-ethyl acetate mixture. The mixture was made alkaline with sodium bicarbonate addition and the organic phase was recovered by decanting. The organic phase was washed with water, dried and evaporated to dryness to obtain 3.3 g of N-propyl-3-(3',4'-diacetoxyphenyl)-piperidine.

後処理

  1. filtrationthe mixture was then filtered
  2. customThe filtrate was evaporated to dryness
  3. additionwith sodium bicarbonate addition
  4. customthe organic phase was recovered
  5. customby decanting
  6. washThe organic phase was washed with water
  7. customdried
  8. customevaporated to dryness

出典と根拠

ORDレコード
ord-141b5958b6c347e685cbdb21ac8ed062
出典データセット
uspto-grants-1978_02
特許番号
US04072685

反応ノート

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