Hydrochloric Acid → Methyl-3-(3,4-dihydro-4-ureido-1(2H)-Naphthylidene)carbazate

HRID 616055ノート

反応式

HRID 616055 の反応式
O=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]([NH:12][C:13]([NH2:15])=[O:14])[CH2:4][CH2:3]1.[C:16]([O:20][CH3:21])(=[O:19])[NH:17][NH2:18].Cl>C(O)C>[CH3:21][O:20][C:16](=[O:19])[NH:17][N:18]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]([NH:12][C:13]([NH2:15])=[O:14])[CH2:4][CH2:3]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 80519Methyl carbazateHCID 3628438Urea, (1,2,3,4-tetrahydro-4-oxo-1-naphthalenyl)-

生成物 1

HCID 70627261Methyl-3-(3,4-dihydro-4-ureido-1(2H)-Naphthylidene)carbazate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 1,2,3,4-tetrahydro-4-oxo-1-naphthylurea (4.5 g), methyl carbazate (4.0 g), 95% ethanol (150 ml) and concentrated hydrochloric acid (2 ml) is heated at reflux for an overnight period. The mixture is cooled to room temperature and the crystals are collected. The product melts at 230° C to 233° C (dec). On recrystallizing from aqueous methanol, the title compound melts at 223° C to 225° C (dec).

後処理

  1. temperatureis heated
  2. temperatureat reflux for an overnight period
  3. customthe crystals are collected
  4. customOn recrystallizing from aqueous methanol

出典と根拠

ORDレコード
ord-80d95cd0ef3d4a34bcd8a254501e139c
出典データセット
uspto-grants-1978_02
特許番号
US04072711

反応ノート

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