Chloromethyl Methyl Ether → N-[4-(Methoxymethoxy)-2-nitrophenyl]acetamide
反応式
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][C:6]=1[N+:12]([O-:14])=[O:13])(=[O:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+].[CH3:21][O:22][CH2:23]Cl>CC(C)=O>[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:21][O:22][CH3:23])=[CH:7][C:6]=1[N+:12]([O-:14])=[O:13])(=[O:3])[CH3:2]参加物
5
実験手順
1.9 G. of 1-acetamido-4-hydroxy-2-nitrobenzene, and 10 g. anhydrous potassium carbonate were stirred at room temperature in 75 ml. acetone and treated with 5 ml. chloromethyl methyl ether over 10 minutes. After a further 10 minutes, the mixture was filtered, evaporated to dryness, and the product filtered through silica gel eluting with 1% methanol to afford 1-acetamido-4-methoxymethoxy-2-nitrobenzene.
後処理
- filtrationthe mixture was filtered
- customevaporated to dryness
- filtrationthe product filtered through silica gel eluting with 1% methanol
出典と根拠
- ORDレコード
- ord-db4a00f1eb434261b047a202bb389dbf
- 出典データセット
- uspto-grants-1978_02
- 特許番号
- US04072696
反応ノート
読み込み中…