2-Methyl-2-thiopseudourea sulfate → Guanidine Sulfate (1:1)

HRID 616174

反応式

HRID 616174 の反応式
CC1[N:3]=[CH:4][NH:5]C=1CSCCN.[S:12]([OH:16])([OH:15])(=[O:14])=[O:13].CSC(=N)[NH2:20]>O>[S:12]([OH:16])([OH:15])(=[O:14])=[O:13].[NH2:3][C:4]([NH2:5])=[NH:20]

参加物

4

反応物 2

HCID 752702-Methyl-2-thiopseudourea sulfateHCID 178433288HCID 178433288、化合物

生成物 1

HCID 499987Guanidine Sulfate (1:1)収率 103.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 4-methyl-5-((2-aminoethyl)thiomethyl)imidazole (19.0 g.) and S-methylisothiourea sulphate (15.1 g.) in water (100 ml.) was heated under reflux for 3 hours. Concentration, acidification with sulphuric acid and dilution with ethanol afforded 2-[(4-methyl-5-imidazolyl)methylthio)ethyl]guanidine sulphate (13.0 g.) m.p. 230°-235° (from aqueous methanol).

後処理

  1. temperatureunder reflux for 3 hours
  2. concentrationConcentration, acidification with sulphuric acid and dilution with ethanol

出典と根拠

ORDレコード
ord-56a2604b547f41c08812b9063b8534ab
出典データセット
uspto-grants-1978_02
特許番号
US04072748

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