2,6-Dihydroxyanthraquinone → 2,6-Bis(2-morpholinoethoxy)anthraquinone dihydrochloride

HRID 616342

反応式

HRID 616342 の反応式
[OH:1][C:2]1[CH:15]=[CH:14][C:13]2[C:12](=[O:16])[C:11]3[C:6](=[CH:7][CH:8]=[C:9]([OH:17])[CH:10]=3)[C:5](=[O:18])[C:4]=2[CH:3]=1.[ClH:19].[Cl:20][CH2:21][CH2:22][N:23]1[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1.[OH-:29].[K+]>O.C1(C)C=CC=CC=1.ClC1C=CC=CC=1>[ClH:20].[ClH:19].[O:26]1[CH2:27][CH2:28][N:23]([CH2:22][CH2:21][O:1][C:2]2[CH:15]=[CH:14][C:13]3[C:12](=[O:16])[C:11]4[C:6](=[CH:7][CH:8]=[C:9]([O:17][CH2:21][CH2:22][N:23]5[CH2:28][CH2:27][O:29][CH2:25][CH2:24]5)[CH:10]=4)[C:5](=[O:18])[C:4]=3[CH:3]=2)[CH2:24][CH2:25]1

参加物

7

反応物 3

HCID 67762,6-DihydroxyanthraquinoneHCID 14797Potassium HydroxideHCID 77210Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1)

生成物 1

HCID 203697702,6-Bis(2-morpholinoethoxy)anthraquinone dihydrochloride

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 1140Toluene溶媒2 回HCID 7964Chlorobenzene溶媒

実験手順

This compound was prepared by the method of Example 3, with the exception that toluene was used as the reaction medium rather than chlorobenzene, from 36 g. (0.15 mole) of 2,6-dihydroxyanthraquinone, 100 g. (0.54 mole) of N-(2-chloroethyl) morpholine hydrochloride, 66g. (1.0 mole) of potassium hydroxide pellets (85%), 400 ml. of toluene and 100 ml. of water. The dihydrocholoride salt was recrystallized twice from isopropanol with enough water added to effect solution. The pure compound melted with decomposition at 288-290° C.; λmax (H2 0) 273 μ, E1cm.1% 778.

後処理

  1. customThe dihydrocholoride salt was recrystallized twice from isopropanol with enough water
  2. additionadded
  3. custommelted with decomposition at 288-290° C.

出典と根拠

ORDレコード
ord-82cee194515f4adb839daa1a4052b408
出典データセット
uspto-grants-1978_02
特許番号
US04073904

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