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Ammonia → N-tert.butyl-3,5-dibromo-2-hydroxy-benzylamine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Tert-Butylamine | HCID 6385 | — |
| 反応物 | 3,5-Dibromosalicylaldehyde | HCID 7024 | — |
| 溶媒 | Formic Acid | HCID 284 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | N-tert.butyl-3,5-dibromo-2-hydroxy-benzylamine hydrochloride | HCID 20308288 | — |
反応手順
7 gm of 3,5-dibromo-salicylaldehyde, 17.5 gm of tert. butylamine and 7.7 gm of formic acid were heated for 6 hours at 70°-80° C. Subsequently, the reaction mixture was admixed with aqueous 2 N ammonia, vigorously shaken, and the precipitate formed thereby was sucked off. The residue was dissolved in ethanol, acidified with ethanolic hydrochloric acid and admixed with ether in order to crystallize the product out. N-tert.butyl-3,5-dibromo-2-hydroxy-benzylamine hydrochloride, m.p. 216°-220° C (decomp.), was obtained after recrystallization from absolute ethanol/ether.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04073942 |
| 出典データセット | uspto-grants-1978_02 |
| ORD ID | ord-3136111fc16f4cebb7a7f3363b4d7f1b |
| 出典メモ | uspto-grants-1978_02 |