Ethanol → Ethyl 2-dimethylaminomethylacrylate
反応式
[CH3:1][N:2]([CH2:4][C:5](=[CH2:9])[C:6]([OH:8])=[O:7])[CH3:3].S(=O)(=O)(O)O.[CH2:15](O)[CH3:16]>>[CH3:1][N:2]([CH2:4][C:5](=[CH2:9])[C:6]([O:8][CH2:15][CH3:16])=[O:7])[CH3:3]参加物
4
実験手順
A solution of the 2-dimethylaminomethylacrylic acid (35 g) compound prepared as in Example 1 in ethanol (350 ml) and concentrated sulphuric acid (60 ml) were boiled under reflux for three hours. The solution was evaporated to half volume and poured into water (1 liter). The aqueous solution was neutralised by the addition of solid sodium carbonate and extracted with ether. Evaporation of the ether solution gave a pale brown oil which was distilled to give a colourless oil (boiling point 84° C/20 mm). The product was identical with that obtained in Example 4.
後処理
- temperatureunder reflux for three hours
- customThe solution was evaporated to half volume
- additionpoured into water (1 liter)
- additionThe aqueous solution was neutralised by the addition of solid sodium carbonate
- extractionextracted with ether
- customEvaporation of the ether solution
- customgave a pale brown oil which
- distillationwas distilled
- customto give a colourless oil (boiling point 84° C/20 mm)
- customthat obtained in Example 4
出典と根拠
- ORDレコード
- ord-3e6ce0bdaeae4f5cb682a9d984b4e87e
- 出典データセット
- uspto-grants-1978_02
- 特許番号
- US04074051
反応ノート
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