Methanesulfonic Acid → 3-Amino-3-(benzylethylamino)-2-cyanopropenenitrile

反応式

[CH2:1]([CH2:8][CH2:9][NH2:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CS(O)(=O)=O.[C:16]([C-:18]([C:21]#[N:22])[C:19]#[N:20])#[N:17].[K+]>>[NH2:22][C:21]([NH:10][CH2:9][CH2:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[C:18]([C:19]#[N:20])[C:16]#[N:17]

参加物

反応物 3

HCID 6395Methanesulfonic Acid

HCID 162593-Phenylpropylamine

HCID 10964525Potassium Tricyanomethanide

生成物 1

HCID 867354833-Amino-3-(benzylethylamino)-2-cyanopropenenitrile収率 70.8%

実験手順

In a similar manner 27.4 g of benzylethylamine and 13 ml (19.2 g) of methanesulfonic acid were allowed to react. The resulting salt was treated with 25.8 g of potassium tricyanomethanide to yield an additional 32 g of 3-amino-3-(benzylethylamino)-2-cyanopropenenitrile, mp 165°-167°.