Water → 2-Ethyl-2,5-dimethyl-1-azaspiro[5.5]undecan-4-one
反応式
[CH2:1]([C:3]1[CH2:8][C:7]([CH2:10][CH3:11])([CH3:9])[NH:6][C:5]2([CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)N=1)[CH3:2].[Br-].[NH4+].[OH2:19]>CO>[CH2:10]([C:7]1([CH3:9])[CH2:8][C:3](=[O:19])[CH:1]([CH3:2])[C:5]2([CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[NH:6]1)[CH3:11]参加物
5
実験手順
11.1 g of the 2,4-diethyl-4-methyl-1,5-diazaspiro[5.5]-undec-1-ene thus obtained and 2.5 g of ammonium bromide were dissolved in 70 ml of methanol. 45 ml of water were added to the solution, with stirring. The mixture was then stirred at room temperature for 8 hours. Methanol was removed by evaporation under reduced pressure and the residue was then distilled under reduced pressure, giving 7.4 g of the title product, bp 119° - 122° C/1.5 mmHg.
後処理
- stirringThe mixture was then stirred at room temperature for 8 hours
- customMethanol was removed by evaporation under reduced pressure
- distillationthe residue was then distilled under reduced pressure
出典と根拠
- ORDレコード
- ord-7b2bd52ea2a143af9a89c30e34c19a40
- 出典データセット
- uspto-grants-1978_02
- 特許番号
- US04075165
反応ノート
読み込み中…