((o-Methoxyphenoxy)methyl)oxirane → 1-[3-(o-Methoxyphenoxy)-2-hydroxypropyl]-4-(2-oxo-hexahydro-1-pyrimidinyl)-piperidine

HRID 616594ノート

反応式

HRID 616594 の反応式
[CH3:1][O:2][C:3]1[CH:13]=[CH:12][CH:11]=[CH:10][C:4]=1[O:5][CH2:6][CH:7]1[O:9][CH2:8]1.[NH:14]1[CH2:19][CH2:18][CH:17]([N:20]2[CH2:25][CH2:24][CH2:23][NH:22][C:21]2=[O:26])[CH2:16][CH2:15]1>C(O)C>[CH3:1][O:2][C:3]1[CH:13]=[CH:12][CH:11]=[CH:10][C:4]=1[O:5][CH2:6][CH:7]([OH:9])[CH2:8][N:14]1[CH2:19][CH2:18][CH:17]([N:20]2[CH2:25][CH2:24][CH2:23][NH:22][C:21]2=[O:26])[CH2:16][CH2:15]1

参加物

4

反応物 2

HCID 98357((o-Methoxyphenoxy)methyl)oxiraneHCID 155726661-(Piperidin-4-yl)-1,3-diazinan-2-one

生成物 1

HCID 203680531-[3-(o-Methoxyphenoxy)-2-hydroxypropyl]-4-(2-oxo-hexahydro-1-pyrimidinyl)-piperidine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 9 g of 1-(o-methoxy-phenoxy)-2,3-epoxypropane and 9.15 g of 1-(4-piperidyl)-2-oxo-hexahydro-pyrimidine in 7 ml of abs. ethanol is heated for 5 hours to 95° C and then evaporated in vacuo. The residue is recrystallised from ethyl acetate/petroleum ether to yield the 1-[3-(o-methoxyphenoxy)-2-hydroxypropyl]-4-(2-oxo-hexahydro-1-pyrimidinyl)-piperidine, which melts at 130°-133° C.

後処理

  1. customevaporated in vacuo
  2. customThe residue is recrystallised from ethyl acetate/petroleum ether

出典と根拠

ORDレコード
ord-33b8f8f97ff047c8ad4246f44733eb12
出典データセット
uspto-grants-1978_02
特許番号
US04075208

反応ノート

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