Sulfuric Acid → 5-Amino-1-methyl-3-(1-methyl-5-nitro-2-imidazolyl)pyrazole-4-carboxamide

HRID 616619ノート

反応式

HRID 616619 の反応式
S(=O)(=O)(O)[OH:2].[NH2:6][C:7]1[N:11]([CH3:12])[N:10]=[C:9]([C:13]2[N:14]([CH3:21])[C:15]([N+:18]([O-:20])=[O:19])=[CH:16][N:17]=2)[C:8]=1[C:22]#[N:23]>C(O)C>[NH2:6][C:7]1[N:11]([CH3:12])[N:10]=[C:9]([C:13]2[N:14]([CH3:21])[C:15]([N+:18]([O-:20])=[O:19])=[CH:16][N:17]=2)[C:8]=1[C:22]([NH2:23])=[O:2]

参加物

4

反応物 2

HCID 1118Sulfuric Acid2 回HCID 203681595-Amino-1-methyl-3-(1-methyl-5-nitro-2-imidazolyl)pyrazole-4-carbonitrile

生成物 1

HCID 203681735-Amino-1-methyl-3-(1-methyl-5-nitro-2-imidazolyl)pyrazole-4-carboxamide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

Another grouping present in these novel compounds, namely the 4-carbonitrile group, can also be utilized to prepare derivatives. This carbonitrile group can be readily hydrolyzed to the 4-carboxamido grouping by allowing the carbonitrile to react with concentrated sulfuric acid in absolute ethanol. Illustratively, when 5-amino-1-methyl-3-(1-methyl-5-nitro-2-imidazolyl)pyrazole-4-carbonitrile is allowed to react with concentrated sulfuric acid in absolute ethanol at steam bath temperature for about one hour, there is obtained 5-amino-1-methyl-3-(1-methyl-5-nitro-2-imidazolyl)-pyrazole-4-carboxamide.

後処理

  1. customto prepare derivatives

出典と根拠

ORDレコード
ord-a3c2d1a2122e4cda9e6e168a45a81905
出典データセット
uspto-grants-1978_02
特許番号
US04075222

反応ノート

読み込み中…