化工社化工社 化学情報印刷レポート · 研究参考用
Phosphorane, ethylidenetriphenyl- → Ethyl alpha-(3,4-dimethoxyphenyl)crotonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosphorane, ethylidenetriphenyl- | HCID 137195 | — |
| 反応物 | Benzeneacetic acid, 3,4-dimethoxy-alpha-oxo-, ethyl ester | HCID 170290 | — |
| 触媒 | Phosphonium, ethyltriphenyl-, bromide (1:1) | HCID 73727 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | Ethyl alpha-(3,4-dimethoxyphenyl)crotonate | HCID 70615010 | — |
反応手順
To a diethyl ether solution of ethylidenetriphenylphosphorane prepared in the usual way from 800 g. of ethyltriphenylphosphonium bromide, 400 g. of ethyl 3,4-dimethoxyphenylglyoxylate in 600 ml. of ether are added dropwise. After refluxing for 4-5 hours, the solvent is evaporated and substituted with tetrahydrofuran. The mixture is then heated for 36 hours and then evaporated to dryness and the residue is extracted with diethyl ether in a Soxhlet apparatus giving 150 g. of the title compound. Pursuant to this procedure, the following other α-arylcrotonate starting materials are prepared:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04075241 |
| 出典データセット | uspto-grants-1978_02 |
| ORD ID | ord-a5755b4f3c46421b8a14187d27c854ba |
| 出典メモ | uspto-grants-1978_02 |