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Alprazolam → 1-[2-(diethylamino)ethyl]-8-chloro-6-phenyl-4H-s-triazolo-[4,3-a][1,4]benzodiazepine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Alprazolam | HCID 2118 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Acetyl chloride | HCID 6367 | — |
| 溶媒 | Tetraethylmethylenediamine | HCID 66020 | — |
| 生成物 | 1-[2-(diethylamino)ethyl]-8-chloro-6-phenyl-4H-s-triazolo-[4,3-a][1,4]benzodiazepine | HCID 12612440 | — |
反応手順
In the manner given in Example 1, a solution of 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine in dimethylformamide, N,N,N',N'-tetraethyldiaminomethane and acetyl chloride (in 0.25 molar excess compared to the N,N,N',N'-tetraethyldiaminomethane) are reacted together to give 8-chloro-1-[2-(diethylamino)ethyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04075221 |
| 出典データセット | uspto-grants-1978_02 |
| ORD ID | ord-6106fbb22fe147938f3282d8c20f8c7f |
| 出典メモ | uspto-grants-1978_02 |