p-Toluenesulfonic acid monohydrate → HCID 20368829、化合物

HRID 616706ノート

反応式

HRID 616706 の反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]2[CH:12]=[C:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[N:14]=[C:4]2[CH:3]=1.[OH2:20].[C:21]1(C)C=C[C:24](S(O)(=O)=O)=[CH:23][CH:22]=1>C(O)CCC>[CH2:21]([O:20][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]2[CH:12]=[C:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[N:14]=[C:4]2[CH:3]=1)[CH2:22][CH2:23][CH3:24]

参加物

4

反応物 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 12763962HCID 12763962、化合物

生成物 1

HCID 20368829HCID 20368829、化合物

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

実験手順

A mixture of ethyl 5-chloroimidazo[1,2-a]quinoline-2-carboxylate 2.75 g. (0.01 mole) and 40 mg. of p-toluenesulfonic acid monohydrate in 150 ml. of n-butanol is heated at 100° C. for 18 hours. The butanol is then removed under reduced pressure. The residue is dissolved in a small amount of chloroform and chromatographed on a silica gel column. The fractions containing the title compound are combined and evaporated to dryness. The product can be further purified by crystallization.

後処理

  1. customThe butanol is then removed under reduced pressure
  2. dissolutionThe residue is dissolved in a small amount of chloroform
  3. customchromatographed on a silica gel column
  4. additionThe fractions containing the title compound
  5. customevaporated to dryness
  6. customThe product can be further purified by crystallization

出典と根拠

ORDレコード
ord-7b2c0e2c2dc34d0e8e496aecb0c4dd0a
出典データセット
uspto-grants-1978_02
特許番号
US04075343

反応ノート

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