Potassium Carbonate → HCID 59361834、化合物

HRID 61673

反応式

HRID 61673 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([C:8]2[N:17]=[C:16]([NH:18][C:19]3[CH:20]=[C:21]4[C:25](=[CH:26][CH:27]=3)[N:24]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[N:23]=[CH:22]4)[C:15]3[C:10](=[CH:11][C:12]([O:40][CH3:41])=[C:13]([O:35][CH2:36][CH2:37][O:38][CH3:39])[CH:14]=3)[N:9]=2)[CH:5]=[CH:6][CH:7]=1.Cl[CH2:43][C:44]([NH:46][CH:47]([CH3:49])[CH3:48])=[O:45].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[CH:47]([NH:46][C:44](=[O:45])[CH2:43][O:1][C:2]1[CH:3]=[C:4]([C:8]2[N:17]=[C:16]([NH:18][C:19]3[CH:20]=[C:21]4[C:25](=[CH:26][CH:27]=3)[N:24]([C:28]([O:30][C:31]([CH3:33])([CH3:34])[CH3:32])=[O:29])[N:23]=[CH:22]4)[C:15]3[C:10](=[CH:11][C:12]([O:40][CH3:41])=[C:13]([O:35][CH2:36][CH2:37][O:38][CH3:39])[CH:14]=3)[N:9]=2)[CH:5]=[CH:6][CH:7]=1)([CH3:49])[CH3:48]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 761712-chloro-N-(1-methylethyl)acetamideHCID 59361970tert-Butyl 5-(2-(3-hydroxyphenyl)-7-methoxy-6-(2-methoxyethoxy)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

生成物 1

HCID 59361834HCID 59361834、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
80 °C

実験手順

To a solution of tert-Butyl 5-(2-(3-hydroxyphenyl)-7-methoxy-6-(2-methoxyethoxy) quinazolin-4-ylamino)-1H-indazole-1-carboxylate (0.400 g, 0.72 mmol) and 2-chloro-N-isopropylacetamide (0.107 g, 0.79 mmol) in DMF (16 mL) was added K2CO3 (0.297 g, 1.44 mmol). The mixture was heated at 80° C. for 72 h. The mixture was concentrated in vacuo and taken on directly into the next step. HPLC retention time 6.76 mins.

後処理

  1. concentrationThe mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-ac9004650c9346899e389dabcad299df
出典データセット
uspto-grants-2016_09
特許番号
US09440961B2

関連ノート

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