N-(3-(4-(1H-indazol-5-ylamino)-6-(2-methoxyethoxy) quinazolin-2-yl)phenyl)butyramide hydrochloride → HCID 25012250、化合物
反応式
Cl.[NH:2]1[C:10]2[C:5](=[CH:6][C:7]([NH:11][C:12]3[C:21]4[C:16](=[CH:17][CH:18]=[C:19]([O:22][CH2:23][CH2:24][O:25][CH3:26])[CH:20]=4)[N:15]=[C:14]([C:27]4[CH:28]=[C:29]([NH:33][C:34](=[O:38])[CH2:35][CH2:36][CH3:37])[CH:30]=[CH:31][CH:32]=4)[N:13]=3)=[CH:8][CH:9]=2)[CH:4]=[N:3]1>Cl>[NH:2]1[C:10]2[C:5](=[CH:6][C:7]([NH:11][C:12]3[C:21]4[C:16](=[CH:17][CH:18]=[C:19]([O:22][CH2:23][CH2:24][O:25][CH3:26])[CH:20]=4)[N:15]=[C:14]([C:27]4[CH:28]=[C:29]([NH:33][C:34](=[O:38])[CH2:35][CH2:36][CH3:37])[CH:30]=[CH:31][CH:32]=4)[N:13]=3)=[CH:8][CH:9]=2)[CH:4]=[N:3]1参加物
3
実験手順
The purified solid was taken up in HCl (4M in 1,4 dioxane, 30 mL) and stirred at RT for 4.5 h. The volatiles were removed in vacuo and the residue was triturated with Et2O to give N-(3-(4-(1H-indazol-5-ylamino)-6-(2-methoxyethoxy) quinazolin-2-yl)phenyl) butyramide hydrochloride (0.091 g, 0.171 mmol, 55% over two steps). MS 497 (M+1). HPLC retention time 5.547 mins.
後処理
- customThe volatiles were removed in vacuo
- customthe residue was triturated with Et2O