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1,2-Dimethylindole → 5-(2-ethyl-5-methyl-3-indolyl)-5-(1-benzyl-5-fluoro-3-indolyl)-3,4-dichloro-2(5H)-furanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,2-Dimethylindole | HCID 13408 | — |
| 反応物 | 1-Benzyl-5-fluoro-1H-indole | HCID 19796639 | — |
| 反応物 | 4-(2-Ethyl-5-methyl-3-indolyl)-2,3-dichloro-4-oxo-2-butenoic acid | HCID 53738561 | — |
| 生成物 | 5-(2-ethyl-5-methyl-3-indolyl)-5-(1-benzyl-5-fluoro-3-indolyl)-3,4-dichloro-2(5H)-furanone | HCID 20442719 | — |
反応手順
Following a procedure similar to that described above in part B of this example except that 4-(2-ethyl-5-methyl-3-indolyl)-2,3-dichloro-4-oxo-2-butenoic acid is used in place of 4-(1,2-dimethyl-3-indolyl)-2,3-dichloro-4-oxo-2-butenoic acid and 1-benzyl-5-fluoroindole is substituted for 1,2-dimethylindole, there is obtained 5-(2-ethyl-5-methyl-3-indolyl)-5-(1-benzyl-5-fluoro-3-indolyl)-3,4-dichloro-2(5H)-furanone (Formula V: R=R3 =H; R1 =CH3CH2 ; R2 =C6H5CH2 ; Y=5-CH3 ; Y1 =5-F).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04075224 |
| 出典データセット | uspto-grants-1978_02 |
| ORD ID | ord-a702d2d5f43045798fe6425e3caa9eaf |
| 出典メモ | uspto-grants-1978_02 |