反応式
[NH2:1][C:2]1[CH:20]=[C:19]([O:21][CH3:22])[CH:18]=[CH:17][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][Cl:16])=[CH:9][CH:8]=1)=[O:5].[CH:23](=O)[C:24]1[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=1.C(O)(=O)C>C(O)C>[Cl:16][CH2:15][CH2:14][O:13][C:10]1[CH:9]=[CH:8][C:7]([N:6]2[C:4](=[O:5])[C:3]3[C:2](=[CH:20][C:19]([O:21][CH3:22])=[CH:18][CH:17]=3)[NH:1][CH:23]2[C:24]2[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=2)=[CH:12][CH:11]=1参加物
5
実験手順
To a solution of 14.9 g (0.0465 mol) of 2-amino-N-[4-(2-chloro-ethoxy)-phenyl]-4-methoxy-benzamide in 300 mL of ethanol was added 5.6 mL (0.0465 mol) of p-anisaldehyde and 30 mL of acetic acid. The reaction mixture was stirred and heated under a mild reflux overnight. After cooling to room temperature, the solvent was evaporated in a rotary evaporator. After the addition of diethyl ether and petroleum ether, the oily residue was chilled on ice. The precipitate that formed was collected by vacuum filtration. An analytical sample (mp 157-158° C. was obtained by recrystallization from ethanol.
後処理
- temperatureheated under
- temperaturea mild reflux overnight
- customthe solvent was evaporated in a rotary evaporator
- additionAfter the addition of diethyl ether and petroleum ether
- temperaturethe oily residue was chilled on ice
- customThe precipitate that formed
- filtrationwas collected by vacuum filtration
- customAn analytical sample (mp 157-158° C. was obtained by recrystallization from ethanol
出典と根拠
- ORDレコード
- ord-9c27583fb6b6467e805c4b8479c0dfba
- 出典データセット
- uspto-grants-1999_09
- 特許番号
- US05948775
関連ノート
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