(S)-(-)-N-Boc-prolinol → (R)-2-Methyl-3-(2-pyrrolidinylmethoxy)pyridine

反応式

C(OC([N:8]1[CH2:12][CH2:11][CH2:10][C@@H:9]1[CH2:13][OH:14])=O)(C)(C)C.ClC1C=C(OC[C@@H]2CCCN2C(OC(C)(C)C)=O)C=NC=1.C(O[C:41]([N:43]1[CH2:47][CH2:46][CH2:45][C@H:44]1[CH2:48]O)=O)(C)(C)C>>[CH3:48][C:44]1[C:45]([O:14][CH2:13][C@H:9]2[CH2:10][CH2:11][CH2:12][NH:8]2)=[CH:46][CH:47]=[CH:41][N:43]=1

参加物

反応物 3

HCID 643448(S)-(-)-N-Boc-prolinol

HCID 688279N-(tert-Butoxycarbonyl)-D-prolinol

HCID 542993835-chloro-3-((1-t-butoxycarbonyl-2-(S)-pyrrolidinyl)methoxy)pyridine

生成物 1

HCID 127922(R)-2-Methyl-3-(2-pyrrolidinylmethoxy)pyridine

実験手順

Replacing (S)-1-t-butoxycarbonyl-2-pyrrolidinemethanol of Example 15 with (R)-1-t-butoxycarbonyl-2-pyrrolidinemethanol (Aldrich Chemical Co.), and following the procedure of steps 15a and 15b, the title compound was prepared. The MS and 1H NMR spectra were similar to compound 15a.

出典と根拠

ORDレコード: ord-80b6a394a4c94df6ab5e52b4ae96a0fd
出典データセット: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05948793

反応ノート

読み込み中…

参加物