Dimethylformamide → 3-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-5methoxy-pyridine-N-oxide
反応式
[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][C@H:3]1[CH2:7][O:8][C:9]1[CH:10]=[N+:11]([O-:16])[CH:12]=[C:13](Br)[CH:14]=1.[C-]#N.[Na+].CN([CH:23]=[O:24])C>O>[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][C@H:3]1[CH2:7][O:8][C:9]1[CH:10]=[N+:11]([O-:16])[CH:12]=[C:13]([O:24][CH3:23])[CH:14]=1参加物
5
実験手順
A sample of 3-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-5bromo-pyridine-N-oxide, from Example 98a above, is reacted with sodium cyanide in DMF and water according to standard procedures. The solvents are removed, and the product is extracted, then purified by chromatography on silica gel.
後処理
- customThe solvents are removed
- extractionthe product is extracted
- custompurified by chromatography on silica gel
出典と根拠
- ORDレコード
- ord-89998bd42b784f44b6e4bbf02bf3ce1e
- 出典データセット
- uspto-grants-1999_09
- 特許番号
- US05948793
反応ノート
読み込み中…