2,6-Dimethylpiperazine → 8-((3R,5S)-3,5-Dimethylpiperazin-1-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile

HRID 61745

反応式

HRID 61745 の反応式
[C:1]([C:3]1[CH:15]=[C:14]2[C:6]([C:7]3[C:8](=[O:30])[C:9]4[CH:21]=[CH:20][C:19](OS(C(F)(F)F)(=O)=O)=[CH:18][C:10]=4[C:11]([CH3:17])([CH3:16])[C:12]=3[NH:13]2)=[CH:5][CH:4]=1)#[N:2].[CH3:31][CH:32]1[CH2:37][NH:36][CH2:35][CH:34]([CH3:38])[NH:33]1>>[CH3:38][C@H:34]1[NH:33][C@@H:32]([CH3:31])[CH2:37][N:36]([C:19]2[CH:20]=[CH:21][C:9]3[C:8](=[O:30])[C:7]4[C:6]5[C:14](=[CH:15][C:3]([C:1]#[N:2])=[CH:4][CH:5]=5)[NH:13][C:12]=4[C:11]([CH3:16])([CH3:17])[C:10]=3[CH:18]=2)[CH2:35]1

参加物

3

反応物 2

HCID 660562,6-DimethylpiperazineHCID 86663817Trifluoro-methanesulfonic acid 3-cyano-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl ester

生成物 1

HCID 668342708-((3R,5S)-3,5-Dimethylpiperazin-1-yl)-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile

実験手順

Under the same conditions as the method for synthesizing Compound B2-1, the title compound was prepared from Compound B1 and 2,6-dimethylpiperazine.

後処理

  1. customUnder the same conditions as the method for synthesizing Compound B2-1

出典と根拠

ORDレコード
ord-d36453e1ab264ca3a53e478ab97c643c
出典データセット
uspto-grants-2016_09
特許番号
US09440922B2

関連ノート

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