Benzo-1,3-dioxole-5-methylamine → 2-Chloro-6-ethyl-4-(3,4-methylenedioxybenzylamino)-thieno-[2,3-d]-pyrimidine

反応式

[CH2:1]1[O:11][C:10]2[CH:9]=[CH:8][C:5]([CH2:6][NH2:7])=[CH:4][C:3]=2[O:2]1.[Cl:12][C:13]1[N:14]=[C:15](Cl)[C:16]2[CH:21]=[C:20]([CH2:22][CH3:23])[S:19][C:17]=2[N:18]=1>>[Cl:12][C:13]1[N:14]=[C:15]([NH:7][CH2:6][C:5]2[CH:8]=[CH:9][C:10]3[O:11][CH2:1][O:2][C:3]=3[CH:4]=2)[C:16]2[CH:21]=[C:20]([CH2:22][CH3:23])[S:19][C:17]=2[N:18]=1

参加物

反応物 2

HCID 75799Benzo-1,3-dioxole-5-methylamine

HCID 184603242,4-Dichloro-6-ethylthieno[2,3-d]pyrimidine

生成物 1

HCID 184601582-Chloro-6-ethyl-4-(3,4-methylenedioxybenzylamino)-thieno-[2,3-d]-pyrimidine

実験手順

Following the procedure of Example 1, the reaction of 3,4-methylenedioxybenzylamine with 2,4-dichloro-6-ethyl-thieno-[2,3-d]-pyrimidine gives 2-chloro-6-ethyl-4-(3,4-methylenedioxybenzylamino)-thieno-[2,3-d]-pyrimidine Mp. 148° C.

出典と根拠

ORDレコード: ord-4f24d0c2f0534f6793709f46f8091183
出典データセット: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05948911

反応ノート

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