Hydrochloric Acid → Methyl 4-(3,4-dihydro-4-oxo-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl)-benzoate

HRID 617512

反応式

HRID 617512 の反応式
[NH2:1][C:2]1[S:3][C:4]([CH3:12])=[CH:5][C:6]=1[C:7]([O:9]CC)=O.[CH3:13][O:14][C:15](=[O:24])[C:16]1[CH:21]=[CH:20][C:19]([C:22]#[N:23])=[CH:18][CH:17]=1.Cl>O1CCOCC1>[CH3:13][O:14][C:15](=[O:24])[C:16]1[CH:21]=[CH:20][C:19]([C:22]2[NH:23][C:7](=[O:9])[C:6]3[CH:5]=[C:4]([CH3:12])[S:3][C:2]=3[N:1]=2)=[CH:18][CH:17]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 70791Methyl 4-cyanobenzoateHCID 4062885Ethyl 2-Amino-5-methylthiophene-3-carboxylate

生成物 1

HCID 23289523Methyl 4-(3,4-dihydro-4-oxo-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl)-benzoate収率 119.2%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

2-Amino-5-methyl-3-ethoxycarbonyl-thiophene (5 g) and 4-cyanobenzoic acid methylester (2.7 g) are dissolved in dioxane (40 ml). Gaseous HCl is conducted through the solution for 5 hours. The usual workup yields 4-(3,4-dihydro-4-oxo-6-methyl-thieno-[2,3-d]-pyrimidin-2-yl]-benzoic acid methylester (6 g)

出典と根拠

ORDレコード
ord-1cd8e040c27e420c96b6a60c232f5dd9
出典データセット
uspto-grants-1999_09
特許番号
US05948911

関連ノート

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