1,1-Dichloroethane → 2-(4-Dodecanoylphenyl)ethyl acetate

HRID 617881

反応式

HRID 617881 の反応式
[Cl-].[Al+3].[Cl-].[Cl-].[C:5]([O:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)(=[O:7])[CH3:6].[C:17](Cl)(=[O:28])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27].Cl[CH:31](Cl)C>>[C:5]([O:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([C:17](=[O:28])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:31])=[CH:13][CH:12]=1)(=[O:7])[CH3:6]

参加物

5

反応物 4

HCID 63651,1-DichloroethaneHCID 76542-Phenylethyl AcetateHCID 87287Undecanoyl chlorideHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 218493882-(4-Dodecanoylphenyl)ethyl acetate

実験手順

Aluminum chloride (48.2 g) was added to dichloroethane (400 ml) in a stream of nitrogen and the mixture was stirred at room temperature. Then, phenethyl acetate (39.6 g) and undecanoyl chloride (52.7 g) were dropwise added thereto under ice-cooling and the mixture was stirred at room temperature overnight. The reaction mixture was poured into ice water and extracted with diethyl ether. The ether layer was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was distilled away and the residue obtained was purified by silica gel column chromatography (eluent; ethyl acetate:hexane=1:20) to give the subject compound (34.5 g) as pale yellow crystals.

後処理

  1. temperatureunder ice-cooling
  2. stirringthe mixture was stirred at room temperature overnight
  3. extractionextracted with diethyl ether
  4. washThe ether layer was washed with saturated brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. distillationThe solvent was distilled away
  7. customthe residue obtained
  8. customwas purified by silica gel column chromatography (eluent; ethyl acetate:hexane=1:20)

出典と根拠

ORDレコード
ord-bcedc3e4f3f94ca7be74657317be12ec
出典データセット
uspto-grants-1999_09
特許番号
US05952316

関連ノート

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