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1-Benzyloxycarbonylamino3-([1,8]naphthyridin-2-yl)-propane → 3-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)propan-1-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Benzyloxycarbonylamino3-([1,8]naphthyridin-2-yl)-propane | HCID 21850009 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | HCID 178418390 | HCID 178418390 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)propan-1-amine | HCID 9877599 | — |
反応手順
A mixture of 1-7 (0.40 g, 1.24 mmol) and 10% Pd/carbon (0.08 g) in EtOH (12 mL) was stirred under a balloon of hydrogen for 20 h. Filtration through a celite pad and then evaporative removal of the filtrate solvent gave 1-8 as a colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05952341 |
| 出典データセット | uspto-grants-1999_09 |
| ORD ID | ord-b76cde09736546e88cde543518f2299b |
| 出典メモ | uspto-grants-1999_09 |