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3',4',5'-Trimethoxyacetophenone → (E)-3-(6-Methoxyindol-3-yl)-1-(3,4,5-trimethoxyphenyl)-2-propen-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3',4',5'-Trimethoxyacetophenone | HCID 14345 | — |
| 反応物 | 6-Methoxy-1H-indole-3-carboxaldehyde | HCID 907214 | — |
| 生成物 | (E)-3-(6-Methoxyindol-3-yl)-1-(3,4,5-trimethoxyphenyl)-2-propen-1-one | HCID 21850283 | 32% |
反応手順
Substantially the same procedure as in Example 1 was repeated using 3',4',5'-trimethoxyacetophenone (659 mg) and 6-methoxyindole-3-carboxaldehyde (550 mg) except that the reaction solution was concentrated under reduced pressure, that the residue was purified by silica gel column chromatography, and that the obtained crude crystals were recrystallized from ethanol, to give Compound 39 (369 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05952355 |
| 出典データセット | uspto-grants-1999_09 |
| ORD ID | ord-f3c262c37ecd43e0955d3e99bad2ecf7 |
| 出典メモ | uspto-grants-1999_09 |