Trifluoroacetate → N-[N'-[3-(1-Piperazinyl)benzoyl]glycyl]-3(S)-ethynyl-beta-alanine trifluoroacetic acid salt
反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:15]=[C:16]([CH:24]=[CH:25][CH:26]=2)[C:17]([NH:19][CH2:20][C:21]([OH:23])=O)=[O:18])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.C([O:30][C:31](=[O:37])[CH2:32][C@@H:33]([C:35]#[CH:36])[NH2:34])C.[F:38][C:39]([F:44])([F:43])[C:40]([O-:42])=[O:41]>>[F:38][C:39]([F:44])([F:43])[C:40]([OH:42])=[O:41].[N:11]1([C:14]2[CH:15]=[C:16]([CH:24]=[CH:25][CH:26]=2)[C:17]([NH:19][CH2:20][C:21]([NH:34][C@H:33]([C:35]#[CH:36])[CH2:32][C:31]([OH:37])=[O:30])=[O:23])=[O:18])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1参加物
4
実験手順
The acid 17-1 was coupled with 3(S)-ethynyl-β-alanine ethyl ester hydrochloride (Zablocki et al., J. Med. Chem., 1995, 38, 2378-2394) using standard peptide coupling conditions. The product was then fully deprotected using previously described methodology to give, after reverse phase chromatography, 17-4 as the trifluoroacetate salt.
後処理
- customto give
出典と根拠
- ORDレコード
- ord-96fba85a7bfe49e9a10bcfac5281a527
- 出典データセット
- uspto-grants-1999_09
- 特許番号
- US05952306
反応ノート
読み込み中…